Synthesis and biological evaluation of 2-amino-4-hydroxy-6-hydroxymethylpteridine pyrophosphate.

@article{Ho1980SynthesisAB,
  title={Synthesis and biological evaluation of 2-amino-4-hydroxy-6-hydroxymethylpteridine pyrophosphate.},
  author={R. I. Ho},
  journal={Methods in enzymology},
  year={1980},
  volume={66},
  pages={
          553-6
        }
}
  • R. I. Ho
  • Published 1980
  • Chemistry, Medicine
  • Methods in enzymology
Abstract A method for synthesizing the title compound is described which represents a distinct improvement over previous procedures in regard to convenience, yield, and purity. IR and proton NMR spectral data are reported for this compound for the first time. The effectiveness of 2-amino-4-hydroxy-6-hydroxy-methylpteridine pyrophosphate as a substrate for the enzyme dihydropteroate synthetase, extracted from both Neisseria gonorrhoeaea , and N. meningitidis , was evaluated. Inhibition of this… Expand
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