Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents.

@article{Scribner2010SynthesisAB,
  title={Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents.},
  author={Andrew Scribner and David Houck and Zhuhui Huang and Sarah M Mosier and Michael D. Peel and Bernard Scorneaux},
  journal={Bioorganic & medicinal chemistry letters},
  year={2010},
  volume={20 22},
  pages={6542-6}
}
An efficient synthesis of [D-lysine](8)cyclosporin A has been developed. Several analogs of [D-lysine](8)cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC(50)<200 nM, and are each ≥50-fold less immunosuppressive than cyclosporin A.