Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.

@article{Zou2011SynthesisAB,
  title={Synthesis and biological evaluation of 2-indolinone derivatives as potential antitumor agents.},
  author={Hongbin Zou and Liang Zhang and Jingfeng Ouyang and Marc A. Giulianotti and Yongping Yu},
  journal={European journal of medicinal chemistry},
  year={2011},
  volume={46 12},
  pages={5970-7}
}
Three series of 3-substituted-indolin-2-ones and azaindolin-2-ones have been synthesized and showed potential antiproliferative activity to cancer cell lines. The inhibition activities on VEGF-induced VEGFR phosphorylation were observed for selected 2-indolinones. Among the compounds synthesized, 5-fluoroindolin-2-one derivative 23 with a pyridone unit… CONTINUE READING