Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.

@article{Nicolaou2011SynthesisAB,
  title={Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues.},
  author={K C Nicolaou and Shelby P Ellery and Fatima Rivas and Karen F. Saye and Eric O. Rogers and Tyler J Workinger and Mark A Schallenberger and Rommel I. Tawatao and Ana Belen Santos Montero and Ann J Hessell and Floyd E Romesberg and Dennis Carson and Dennis T Burton},
  journal={Bioorganic & medicinal chemistry},
  year={2011},
  volume={19 18},
  pages={5648-69}
}
Most nucleosides in solution typically exist in equilibrium between two major sugar pucker forms, N-type and S-type, but bridged nucleosides can be locked into one of these conformations depending on their specific structure. While many groups have researched these bridged nucleosides for the purpose of determining their binding affinity for antisense applications, we opted to look into the potential for biological activity within these conformationally-locked structures. A small library of 2… CONTINUE READING

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International Patent WO 031505 A 1 ,

  • K. A. Jacobson, B. V. Joshi, S. Tchilibon
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