Synthesis and biological activity of the mono- and di-galactosyl-vespulakinin 1 analogues.

@article{Gobbo1992SynthesisAB,
  title={Synthesis and biological activity of the mono- and di-galactosyl-vespulakinin 1 analogues.},
  author={Marina Gobbo and Laura Biondi and Fernando Filira and Barbara Scolaro and Raniero Rocchi and Tom Piek},
  journal={International journal of peptide and protein research},
  year={1992},
  volume={40 1},
  pages={
          54-61
        }
}
  • M. Gobbo, L. Biondi, +3 authors T. Piek
  • Published 1992
  • Chemistry, Medicine
  • International journal of peptide and protein research
Syntheses are described of some mono- and di-glycosylated analogues of vespulakinin 1. The solid phase procedure, based on the Fmoc chemistry, was used to prepare (Gal alpha)Thr3-vespulakinin 1, (Gal beta)Thr3-vespulakinin 1 and the di-glycosylated analogue ((Gal alpha)Thr3, (Gal alpha)Thr4-vespulakinin 1. The beta-glycosylated derivative was also prepared by the continuous flow variant of the Fmoc polyamide method. The synthesized glycopeptides were purified and characterized by amino acid… Expand
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Preliminary pharmacological experiments indicated that carbohydrate-free vespulakinin 1 is more potent than bradykinin in lowering rat blood pressure. Expand
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Two structurally similar and highly active glycopeptides have been isolated from extracts of yellow jacket venom sacs by ion-exchange and droplet countercurrent chromatography procedures, both of which report the presence of carbohydrate. Expand
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The title esters are effective acylating agents in solid phase peptide synthesis; completion of acylation is indicated by fading of the transient yellow colour produced by ionisation of the liberatedExpand
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Details are given of a novel technique for solid-phase peptide synthesis under continuous flow conditions. The resin support is a poly(dimethylacrylamide) gel polymerised within the pores of rigidExpand
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