Synthesis and biological activity of the mono- and di-galactosyl-vespulakinin 1 analogues.

  title={Synthesis and biological activity of the mono- and di-galactosyl-vespulakinin 1 analogues.},
  author={Marina Gobbo and Laura Biondi and Fernando Filira and Barbara Scolaro and Raniero Rocchi and Tom Piek},
  journal={International journal of peptide and protein research},
  volume={40 1},
  • M. Gobbo, L. Biondi, +3 authors T. Piek
  • Published 1992
  • Chemistry, Medicine
  • International journal of peptide and protein research
Syntheses are described of some mono- and di-glycosylated analogues of vespulakinin 1. The solid phase procedure, based on the Fmoc chemistry, was used to prepare (Gal alpha)Thr3-vespulakinin 1, (Gal beta)Thr3-vespulakinin 1 and the di-glycosylated analogue ((Gal alpha)Thr3, (Gal alpha)Thr4-vespulakinin 1. The beta-glycosylated derivative was also prepared by the continuous flow variant of the Fmoc polyamide method. The synthesized glycopeptides were purified and characterized by amino acid… Expand
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