Synthesis and biological activity of some derivatives of thiochroman-4-one and tetrahydrothiapyran-4-one.

@article{Ramalingam1977SynthesisAB,
  title={Synthesis and biological activity of some derivatives of thiochroman-4-one and tetrahydrothiapyran-4-one.},
  author={Kondareddiar Ramalingam and George X. Thyvelikakath and K. Darrell Berlin and Robert W. Chesnut and Roger Allen Brown and Norman N. Durham and Steven E. Ealick and Dick van der Helm},
  journal={Journal of medicinal chemistry},
  year={1977},
  volume={20 6},
  pages={
          847-50
        }
}
  • Kondareddiar Ramalingam, George X. Thyvelikakath, +5 authors Dick van der Helm
  • Published in
    Journal of medicinal…
    1977
  • Chemistry, Medicine
  • A small series of pyrazoles and isoxazoles derived from thiochroman-4-one has been synthesized and characterized. The compounds were examined for their in vitro inhibitory activity against Bacillus subtilis and Pseudomonas fluorescens. Among the tested compounds the pyrazole derivative from thiochroman-4-one was found to be the most effective inhibitor of growth of B. subtilis. Extensive H NMR analysis was recorded for all compounds. 

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