Synthesis and biological activity of some antitumor benzophenanthridinium salts.

@article{Stermitz1975SynthesisAB,
  title={Synthesis and biological activity of some antitumor benzophenanthridinium salts.},
  author={Frank R. Stermitz and Jeromey Gillespie and L G Amoros and Remedios Romero and T A Stermitz and Karen A. Larson and S Earl and Jack Ogg},
  journal={Journal of medicinal chemistry},
  year={1975},
  volume={18 7},
  pages={708-13}
}
A facil synthesis of benzophenanthridinium salts has been developed and used for preparing a number of these compounds. The antitumor activities in mouse leukemia L1210 (LE) and P388 (PS) were determined as well as some selected antimicrobial activities. Although antitumor activity was exhibited by several of the derivatives, none was as active as the naturally occurring alkaloid fagaronine. Fagaronine was made available as a synthetic by an improved procedure. Some structure-activity… CONTINUE READING