Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands.

Abstract

As a continuation of our search for novel histamine H3 receptor ligands a series of twenty new tert-amyl phenoxyalkylamine derivatives (2-21) was synthesized. Compounds of four to eight carbon atoms spacer alkyl chain were evaluated on their binding properties at human histamine H3 receptor (hH3R). The highest affinities were observed for pentyl derivatives… (More)
DOI: 10.1016/j.bmc.2017.03.031

Topics

13 Figures and Tables

Cite this paper

@article{Kuder2017SynthesisAB, title={Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands.}, author={Kamil J Kuder and Dorota Łażewska and Maria Kaleta and Gniewomir Latacz and Tim Kottke and Agnieszka Olejarz and Tadeusz Karcz and Andrzej Fruziński and Katarzyna Szczepańska and Janina Karolak-Wojciechowska and Holger Stark and Katarzyna Kiec-Kononowicz}, journal={Bioorganic & medicinal chemistry}, year={2017}, volume={25 10}, pages={2701-2712} }