Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles.

@article{Roth1997SynthesisAB,
  title={Synthesis and biological activity of novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 2-Aryl-substituted benzimidazoles.},
  author={Tova Roth and MarkW. Morningstar and Paul L. Boyer and Stephen H. Hughes and Robert W. Buckheit and Christopher J. Michejda},
  journal={Journal of medicinal chemistry},
  year={1997},
  volume={40 26},
  pages={4199-207}
}
The development of new nonnucleoside inhibitors of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) active against the drug-induced mutations in RT continues to be a very important goal of AIDS research. We used a known inhibitor of HIV-1 RT, 1-(2,6-difluorophenyl)-1H,3H-thiazolo[3,4-alpha]benzimidazole (TZB), as the lead structure for drug design with the objective of making more potent inhibitors against both wild-type (WT) and variant RTs. A series of structurally… CONTINUE READING

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