Synthesis and biological activity of novel 5'-arylamino-nucleosides by microwave-assisted one-pot tandem Staudinger/aza-Wittig/reduction.

@article{Chen2011SynthesisAB,
  title={Synthesis and biological activity of novel 5'-arylamino-nucleosides by microwave-assisted one-pot tandem Staudinger/aza-Wittig/reduction.},
  author={Hua Chen and Jianpeng Zhao and Yanan Li and Fengjuan Shen and Xiao-liu Li and Qingmei Yin and Zhanbin Qin and Xinhao Yan and Yanfei Wang and Pingzhu Zhang and Jinchao Zhang},
  journal={Bioorganic & medicinal chemistry letters},
  year={2011},
  volume={21 1},
  pages={574-6}
}
Novel pseudonucleosides with benzylamino group on 5'-position (4) were synthesized by using the microwave-assisted one-pot tandem Staudinger/aza-Wittig/reduction reaction in good yields of 55.2-71.7%. The deacetylation of 4 afforded compounds 5. HIV-1 reverse transcriptase (RT) inhibitory and antitumor activities were preliminarily evaluated with 5. The… CONTINUE READING