Synthesis and biological activity of novel tiliroside derivants.

  title={Synthesis and biological activity of novel tiliroside derivants.},
  author={Nan Qin and Chun-bao Li and Mei-na Jin and L H Shi and Hong-quan Duan and Wen-yan Niu},
  journal={European journal of medicinal chemistry},
  volume={46 10},
A series of new tiliroside derivatives were synthesized and characterized by analytical (1)H NMR, (13)C NMR and mass spectrometry. All of the compounds were evaluated for anti-diabetic properties in vitro using HepG2 cells. Compounds 3c, 3d, and 3i-l caused significant enhancements in glucose consumption by insulin-resistant HepG2 cells compared with control cells and cells that were exposed to metformin (an anti-diabetic drug). Moreover, compound 3l significantly activated adenosine 5… CONTINUE READING

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