Synthesis and biological activity of new diazenedicarboxamides as potential anticancer agents.

@article{Vajs2013SynthesisAB,
  title={Synthesis and biological activity of new diazenedicarboxamides as potential anticancer agents.},
  author={Jure Vajs and Sanja Sovi{\vc}ek and Petra Kureljak and Nikolina Stojanovi{\'c} and Ivana Steiner and Domagoj Eljuga and Damijana Urankar and M. Kocevar and Janez Ko{\vs}mrlj and Slovenko Polanc and Maja Osmak},
  journal={Acta chimica Slovenica},
  year={2013},
  volume={60 4},
  pages={
          842-52
        }
}
To increase the effectiveness of cancer treatment, more effective anti-cancer drugs, as well as the new improved strategies of cancer treatment, are urgently needed. Our previous results have shown that various diazenes are cytotoxic to different tumor cells and can even revert the resistance to cisplatin and vincristine. We also demonstrated that unsymmetrical diazenedicarboxamides 1 and 2 exhibited promising cytotoxicity. The aim of the present study was to synthesize new… CONTINUE READING

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