Synthesis and biological activity of mono- and diamides of 2,3-secotriterpene acids

@article{Tolmacheva2013SynthesisAB,
  title={Synthesis and biological activity of mono- and diamides of 2,3-secotriterpene acids},
  author={I. A. Tolmacheva and E. V. Igosheva and Yu. B. Vikharev and V. V. Grishko and O. Savinova and E. Boreko and V. Eremin},
  journal={Russian Journal of Bioorganic Chemistry},
  year={2013},
  volume={39},
  pages={186-193}
}
Amides of four types were synthesized derived from 2,3-seco-18αH-oleanane and 2,3-secolupane mono- and dicarboxylic acids. The spectrum of diamide derivatives was expanded with C3-C3′ and C28-C28′ biscondensed amides with two A-secotriterpene backbones obtained by the interaction of monocarboxylic A-seco acids with lysine. Among the synthesized monoand diamide derivatives, potential inhibitors of herpes simplex virus type 1 replication were found, namely, some compounds with an ethyl… Expand

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