Synthesis and biological activity of glycyrrhetinic acid derivatives as antitumor agents.

@article{Zhou2019SynthesisAB,
  title={Synthesis and biological activity of glycyrrhetinic acid derivatives as antitumor agents.},
  author={Fanchao Zhou and Gao-Rong Wu and De-Sheng Cai and Bing Xu and Meng-meng Yan and Tao Ma and Wenbo Guo and Wen-xi Zhang and Xue-Mei Huang and Xiao-hui Jia and Yu-qin Yang and Fu-yong Gao and Penglong Wang and Haimin Lei},
  journal={European journal of medicinal chemistry},
  year={2019},
  volume={178},
  pages={
          623-635
        }
}
Glycyrrhetinic acid (GA) had been the star anticancer lead compound and appealed to many scientists all over the world; however, its antitumor activity was not potent enough. To improve GA's cytoxicity and explore the effect of bonding mode on antitumor activity, 32 compounds including GA-OH series (GO, esters in C-3 position) and GA-NH2 series (GN, with amide linkages in C-3 position) had been designed and synthesized. All the compounds were screened for in vitro cytotoxicity against A549… CONTINUE READING