Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.

@article{Peretto2005SynthesisAB,
  title={Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion.},
  author={Ilaria Peretto and Stefano Radaelli and Carlo Parini and Michele Zandi and Luca Francesco Raveglia and Giulio M Dondio and Laura Fontanella and Paola Misiano and Chiara Bigogno and Andrea Rizzi and Benedetta Riccardi and Marcello Biscaioli and Silvia Marchetti and Paola Puccini and Silvia Catinella and Ivano Rondelli and Valentina Cenacchi and Pier Tonino Bolzoni and P Caruso and Gino Villetti and Fabrizio Facchinetti and Elda Del Giudice and Nadia Moretto and Bruno Pietro Imbimbo},
  journal={Journal of medicinal chemistry},
  year={2005},
  volume={48 18},
  pages={5705-20}
}
Flurbiprofen, a nonsteroidal antiinflammatory drug (NSAID), has been recently described to selectively inhibit beta-amyloid(1)(-)(42) (Abeta42) secretion, the most toxic component of the senile plaques present in the brain of Alzheimer patients. The use of this NSAID in Alzheimer's disease (AD) is hampered by a significant gastrointestinal toxicity associated with cyclooxygenase (COX) inhibition. New flurbiprofen analogues were synthesized, with the aim of increasing Abeta42 inhibitory potency… CONTINUE READING
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