Synthesis and biological activity of alpha-methylene-gamma-lactones as new aroma chemicals.

@article{Miyazawa2000SynthesisAB,
  title={Synthesis and biological activity of alpha-methylene-gamma-lactones as new aroma chemicals.},
  author={Mitsuo Miyazawa and Hiroshi Shimabayashi and Sayaka Hayashi and Seiji Hashimoto and Sayaka Nakamura and Hidekazu Kosaka and Hiromu Kameoka},
  journal={Journal of agricultural and food chemistry},
  year={2000},
  volume={48 11},
  pages={5406-10}
}
Seven kinds of alpha-methylene-gamma-lactones with an alkyl group at the C-4 position were synthesized according to a previously described method, with yields of 28-34%. These alpha-methylene-gamma-lactones had characteristic and unique odors. All alpha-methylene-gamma-lactones added a roast-like odor to materials. The antimicrobial effects of alpha-methylene-gamma-lactones were investigated by using a paper disk diffusion method. The results showed the alpha-methylene-gamma-lactones inhibited… CONTINUE READING