Synthesis and biological activity of an icosapeptide analog of the actomyosin ATPase inhibitory region of troponin I.

@article{Talbot1979SynthesisAB,
  title={Synthesis and biological activity of an icosapeptide analog of the actomyosin ATPase inhibitory region of troponin I.},
  author={James A. Talbot and Robert S. Hodges},
  journal={The Journal of biological chemistry},
  year={1979},
  volume={254 10},
  pages={3720-3}
}
A 20-residue peptide analog of the actomyosin ATPase inhibitory region of rabbit skeletal troponin I (Tn-I) has been synthesized by the solid phase method. The analog exhibited biological activity similar to both Tn-I and a 21-residue cyanogen bromide fragment of Tn-I. At ionic strengths where the inhibition of the actomyosin ATPase due to tropomyosin alone is low, the synthetic peptide in the presence of tropomyosin inhibits 90% of the original ATPase activity. In the absence of tropomyosin… CONTINUE READING

From This Paper

Topics from this paper.
8 Citations
0 References
Similar Papers