Synthesis and biological activity of amides of 28-methoxy-28-oxo-1-cyano-2,3-seco-lup-20(29)-en-3-oic acid

@article{Igosheva2012SynthesisAB,
  title={Synthesis and biological activity of amides of 28-methoxy-28-oxo-1-cyano-2,3-seco-lup-20(29)-en-3-oic acid},
  author={E. V. Igosheva and I. A. Tolmacheva and Yu. B. Vikharev and V. V. Grishko and O. Savinova and E. Boreko and V. Eremin},
  journal={Chemistry of Natural Compounds},
  year={2012},
  volume={48},
  pages={426-431}
}
New A-seco-lupane C-3 amide conjugates were prepared by the reaction of 28-methoxy-28-oxo-1-cyano2,3-seco-lup-20(29)-en-3-oic acid chloride with primary amines and synthetic and natural amino acids. Ethyl-N-[28-methyl-28-oxo-1-cyano-2,3-seco-lup-20(29)-en-3-oyl]-β-alaninate, which was cytotoxic against rhabdomyosarcoma tumor cells (IC50 47.5 μM), in addition to ethyl-N-[28-methoxy-28-oxo-1-cyano-2,3-seco-lup-20(29)-en-3-oyl]glycinate and N-[28-methyl-28-oxo-1-cyano-2,3-seco-lup-20(29)-en-3-oyl… Expand
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