Synthesis and biological activity of 5-fluoroimidazole-TRH.


The 5-fluoroimidazole analogue of thyrotropin-releasing hormone, obtained by total synthesis from 5-fluoro-L-histidine, neither binds to rat pituitary cells nor stimulates release of prolactin from them. Lévine-Pinto et. al. reported an agonist, which was generated during presumptive photofluorination of the hormone and which they believed to be the 5… (More)


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@article{Labroo1983SynthesisAB, title={Synthesis and biological activity of 5-fluoroimidazole-TRH.}, author={V M Labroo and Kevin L. Kirk and Lisa Alvarez - Cohen and Dana{\"e} Delbeke and Priscilla S. Dannies}, journal={Biochemical and biophysical research communications}, year={1983}, volume={113 2}, pages={581-5} }