Synthesis and biological activity of 2-amino-1-oxa-2,3-dihydro-1-H-phenalene derivatives.

Abstract

The preparation of two 2-dialkylamino-1-oxa-2,3-dihydro-1H-phenalenes (3 and 4) is described. Lewis acid-catalyzed Baeyer-Villiger reaction of acenaphthenone (5) gave the lactone 6. Reduction afforded the lactol 7, which was reacted with amines to give the target compounds 3 and 4. Investigation of the effects of these compounds on catechol and indole… (More)

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@article{Wang1990SynthesisAB, title={Synthesis and biological activity of 2-amino-1-oxa-2,3-dihydro-1-H-phenalene derivatives.}, author={W. Y. Wang and J. P. Freeman and Maria Burian and P F Vonvoigtlander and Jacqueline R. Szmuszkovicz}, journal={Drug design and delivery}, year={1990}, volume={6 3}, pages={177-82} }