Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents.

@article{Miandji2012SynthesisAB,
  title={Synthesis and biological activities of some 1,3-benzoxazol-2(3H)-one derivatives as anti-quorum sensing agents.},
  author={Anooshirvan M. Miandji and Seyhan Ulusoy and Yasemin D{\"u}ndar and Selda Ozgen and Fatma Kaynak Onurdağ and G{\"u}lg{\"u}n Boşgelmez-Tınaz and Ningur Noyanalpan},
  journal={Arzneimittel-Forschung},
  year={2012},
  volume={62 7},
  pages={
          330-4
        }
}
Antibiotics are commonly used to treat microbial infections. Due to misuse or large-scale use of antibiotics, many pathogens have gained resistance which makes antibiotic treatments ineffective. The discovery that many bacteria use quorum sensing (QS) to regulate their virulence factor and pathogenicity production makes the QS system an attractive target for antimicrobial therapy. A series of 1,3-benzoxazol-2(3H)-one derivatives were designed and synthesized as QS inhibitors (QSIs) and tested… CONTINUE READING
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