Synthesis and biological activities of flavolipids

@article{Ahad2010SynthesisAB,
  title={Synthesis and biological activities of flavolipids},
  author={Samiul M. Ahad and A. L. Ange and R. Bates and Bonnie L. Bell and A. Bodour and B. Bourne and C. G. Contreras and E. Goldberg and A. Gunatilaka and S. King and A. K. Lee and Rebecca L. Low and R. Maier and Kathryn M. Marlor and M. Marron and Ryan Scolnik and M. Streeter and M. Strelczuk and Long N Trinh and Vu Truong and S. Vissering and Megan C. Weick and M. T. Williams},
  journal={Tetrahedron},
  year={2010},
  volume={66},
  pages={9107-9112}
}
  • Samiul M. Ahad, A. L. Ange, +20 authors M. T. Williams
  • Published 2010
  • Chemistry
  • Tetrahedron
  • Syntheses of the bacterial surfactants 6S,6S-, 9S,9S-, and 9U,9U-flavolipids confirmed the structures proposed for them from spectroscopic analysis of a flavolipid mixture and made pure flavolipids available for the first time. All three synthetic flavolipids and a straight chain analogue were found to be weakly cytotoxic and to inhibit metastatic cancer cell migration, with 9U,9U-flavolipid (the most abundant natural flavolipid) having the most activity. Biosynthetic routes to the branched… CONTINUE READING
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