Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors.

Abstract

4-Hydroxyphenylpyruvate dioxygenase (HPPD), an essential enzyme in tyrosine catabolism, is an important target for treating type I tyrosinemia. Inhibition of HPPD can effectively alleviate the symptoms of type I tyrosinemia. However, only one commercial HPPD inhibitor, 2-(2-nitro-4-trifluoromethylbenzoyl) cyclohexane-1,3-dione (NTBC), has been available for… (More)
DOI: 10.1016/j.ejmech.2015.01.018

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@article{Xu2015SynthesisAB, title={Synthesis and bioevaluation of pyrazole-benzimidazolone hybrids as novel human 4-Hydroxyphenylpyruvate dioxygenase inhibitors.}, author={Yu-Ling Xu and Hongyan Lin and Xu Zhi Ruan and Sheng-Gang Yang and Ge-Fei Hao and Wen-Chao Yang and Guangfu Yang}, journal={European journal of medicinal chemistry}, year={2015}, volume={92}, pages={427-38} }