Synthesis and biodistribution of a short nonionic oligonucleotide analogue in mouse with a potential to mimic peptides.

@article{Eschgfaeller1998SynthesisAB,
  title={Synthesis and biodistribution of a short nonionic oligonucleotide analogue in mouse with a potential to mimic peptides.},
  author={Bernd Eschgfaeller and Marcel Koenig and Franziska Boess and Urs Alex Boelsterli and Steven A. Benner},
  journal={Journal of medicinal chemistry},
  year={1998},
  volume={41 3},
  pages={
          276-83
        }
}
A nonionic RNA analogue of the sequence r(USO2GSO2ASO2C) has been synthesized where each bridging phosphate diester is replaced by a dimethylene sulfone unit (rSNA). The rSNA was synthesized in solution from 3',5'-bishomo-beta-ribonucleoside derivatives as building blocks. Full experimental procedures are provided, and the product and all synthetic intermediates are fully characterized. The tetramer is nonionic but highly dipolar due to multiple hydrogen bonding opportunities. It is freely… CONTINUE READING

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