Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase.

@article{Lakanen1995SynthesisAB,
  title={Synthesis and biochemical evaluation of adenosylspermidine, a nucleoside-polyamine adduct inhibitor of spermidine synthase.},
  author={John R. Lakanen and Anthony E. Pegg and James K. Coward},
  journal={Journal of medicinal chemistry},
  year={1995},
  volume={38 14},
  pages={
          2714-27
        }
}
  • John R. Lakanen, Anthony E. Pegg, James K. Coward
  • Published in
    Journal of medicinal…
    1995
  • Chemistry, Medicine
  • The synthesis of a new class of multisubstrate adduct inhibitors of polyamine biosynthesis has been investigated. The first target compound, designed to inhibit spermidine synthase, was obtained and proved to be a very potent inhibitor of that enzyme. Two synthetic routes to effect the coupling of the polyamine spermidine to the nucleoside adenosine were studied. The first route involved a proposed Wittig or Julia olefination reaction to form the critical 5'-6' carbon-carbon bond between the… CONTINUE READING

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