Synthesis and bio-molecular study of (+)-N-Acetyl-α-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma

  title={Synthesis and bio-molecular study of (+)-N-Acetyl-$\alpha$-amino acid dehydroabietylamine derivative for the selective therapy of hepatocellular carcinoma},
  author={Muhammad Ayaz Mustufa and Cigdem Ozen and Imran Ali Hashmi and Afshan Aslam and Jameel Ahmed Baig and Gokhan Yildiz and Shoaib Muhammad and Imam Bakhsh Solangi and Naim ul Hasan Naqvi and Mehmet Ozturk and Firdous Imran Ali},
  journal={BMC Cancer},
BackgroundThe purpose of present work is to synthesize novel (+)-Dehydroabietylamine derivatives (DAAD) using N-acetyl-α-amino acid conjugates and determine its cytotoxic effects on hepatocellular carcinoma cells.MethodsAn analytical study was conducted to explore cytotoxic activity of DAAD on hepatocellular carcinoma cell lines. The cytotoxicity effect was recorded using sulforhodamine B technique. Cell cycle analysis was performed using Propidium Iodide (PI) staining. Based on cell morphology… 
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