Synthesis and binding studies of novel di-substituted phenanthroline compounds with genomic promoter and human telomeric DNA G-quadruplexes.

@article{Wei2013SynthesisAB,
  title={Synthesis and binding studies of novel di-substituted phenanthroline compounds with genomic promoter and human telomeric DNA G-quadruplexes.},
  author={Chunying Wei and Yanbo Wang and Meiying Zhang},
  journal={Organic \& biomolecular chemistry},
  year={2013},
  volume={11 14},
  pages={
          2355-64
        }
}
Six novel di-substituted phenanthroline derivatives 5a-7a and 3b-5b have been prepared, and their binding interactions with human telomeric (h-telo) and promoter (c-kit2 and c-myc) G-quadruplex DNAs were investigated. All the compounds are potent stabilisers of the G-quadruplex structures and compounds 3b, 4b, and 5b exhibit high G-quadruplex DNA selectivity over duplex DNA. The binding affinities of these compounds to G-quadruplex DNA are higher than to duplex DNA. CD spectra show that the… 
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Interactions of terpyridines and their Pt(II) complexes with G-quadruplex DNAs and telomerase inhibition.
New 2,9-disubstituted-1,10-phenanthroline derivatives with anticancer activity by selective targeting of telomeric G-quadruplex DNA.
Human telomeric G-quadruplex DNA interactions of N-phenanthroline glycosylamine copper(II) complexes.
Phenanthroline-bis-oxazole ligands for binding and stabilization of G-quadruplexes.
A Selective G-Quadruplex DNA-Stabilizing Ligand Based on a Cyclic Naphthalene Diimide Derivative
TLDR
A cyclic naphthalene diimide (cyclic NDI, 1), carrying a benzene moiety as linker chain, was synthesized and its interaction with G-quadruplex DNAs was studied based on UV-VIS and circular dichroism spectroscopic techniques, thermal melting temperature measurement, and FRET-melting assay.
Selective recognition of specific G-quadruplex vs. duplex DNA by a phenanthroline derivative.
Phenanthroline-2,9-bistriazoles as selective G-quadruplex ligands.
Targeting Promoter G‐Quadruplex DNAs by Indenopyrimidine‐Based Ligands
TLDR
The synthesis and binding interactions of indenopyrimidine derivatives, endowed with drug‐like properties, with oncogenic promoters of c‐myc and c‐kit, telomeric and duplex DNAs are reported.
Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand.
Mechanism studies on anti-HepG2 cell proliferation of phenanthroline derivatives as G-quadruplex DNA stabilizers.
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