Synthesis and autoradiographic localization of muscarinic cholinergic antagonist (+)N-[11C]methyl-3-piperidyl benzilate as a potent radioligand for positron emission tomography.

@article{Takahashi1999SynthesisAA,
  title={Synthesis and autoradiographic localization of muscarinic cholinergic antagonist (+)N-[11C]methyl-3-piperidyl benzilate as a potent radioligand for positron emission tomography.},
  author={Kuniyuki Takahashi and Matsutaro Murakami and Shuichi Miura and Hidehiro Iida and Iwao Kanno and Kazuo Uemura},
  journal={Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine},
  year={1999},
  volume={50 3},
  pages={521-5}
}
(+)N-[11C]methyl-3-piperidyl benzilate, a relatively low affinity muscarinic cholinergic receptor antagonist was synthesized by N-[11C]methylation of (+)3-piperidyl benzilate using [11C]methyl iodide. The product was isolated by HPLC, and obtained with radiochemical yield of 60-70% from [11C]methyl iodide, and a specific activity of 500-1000 Ci mmol-1 (18.5-37 GBq mumol-1) at EOS and radiochemical purity of > 98%. In vitro autoradiographic studies showed selective binding for this radiotracer… CONTINUE READING