Synthesis and assignment of the absolute configuration of indenotryptoline bisindole alkaloid BE-54017.

@article{Kimura2012SynthesisAA,
  title={Synthesis and assignment of the absolute configuration of indenotryptoline bisindole alkaloid BE-54017.},
  author={T. Kimura and Shuhei Kanagaki and Yusuke Matsui and M. Imoto and Takumi Watanabe and M. Shibasaki},
  journal={Organic letters},
  year={2012},
  volume={14 17},
  pages={
          4418-21
        }
}
Synthesis of the indenotryptoline bisindole alkaloid, BE-54017, was accomplished using osmium-promoted cis-dihydroxylation of maleimide as a key step. After optical resolution, the absolute configuration of this molecule was determined by comparing its optical rotation and HPLC profile to those obtained for BE-54017 derived from enantiopure cladoniamide A, whose stereochemistry has been reported previously. BE-54017 with the correct absolute stereochemistry induced apoptosis of epidermal growth… Expand
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Synthetic Biology Approaches to New Bisindoles.
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