Synthesis and application of dipeptides; current status and perspectives

@article{Yagasaki2008SynthesisAA,
  title={Synthesis and application of dipeptides; current status and perspectives},
  author={M. Yagasaki and S. Hashimoto},
  journal={Applied Microbiology and Biotechnology},
  year={2008},
  volume={81},
  pages={13-22}
}
The functions and applications of l-α-dipeptides (dipeptides) have been poorly studied compared with proteins or amino acids. Only a few dipeptides, such as aspartame (l-aspartyl-l-phenylalanine methyl ester) and l-alanyl-l-glutamine (Ala-Gln), are commercially used. This can be attributed to the lack of an efficient process for dipeptide production though various chemical or chemoenzymatic method have been reported. Recently, however, novel methods have arisen for dipeptide synthesis including… Expand
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In this review, known functions and occurrence of dipeptides are reviewed first since many readers may not be familiar with diPEptides, then a few important studies on the biosynthesis of di peptide manufacturing are summarized followed by a description of the emerging technologies for dipeptic manufacturing based on the recent findings. Expand
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A novel and efficient enzymatic method for the production of oligopeptides, which has wide substrate specificity--both for acyl donors and nucleophiles--and can catalyze peptide-forming reactions to produce various dipeptides from the corresponding amino acid esters and amino acids. Expand
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