Synthesis and antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclobutane ring. Part 1: Guanosine analogues.

@article{Figueira1999SynthesisAA,
  title={Synthesis and antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclobutane ring. Part 1: Guanosine analogues.},
  author={Mar{\'i}a Jos{\'e} Figueira and Jos{\'e} Manuel Blanco and Olga Caama{\~n}o and Fernando Alvarez Tostado Fern{\'a}ndez and Xerardo Garc{\'i}a-Mera and Carmen V{\'a}zquez L{\'o}pez},
  journal={Archiv der Pharmazie},
  year={1999},
  volume={332 10},
  pages={348-52}
}
Five new carbocyclic nucleosides were prepared by constructing a guanine (compounds 3, 5) or 8-azaguanine (compounds 4, 6, and 7) base on the amino group of (1'S,3'R)-3-(3'-amino-2',2'-dimethylcyclobutyl)propan-1-ol (8), and their activities against a variety of viruses and tumor cell lines were determined. Only compounds 3 and 7 showed a detectable… CONTINUE READING