Synthesis and antiviral activity of fluorinated pyrido[1,2-a]benzimidazoles


Methods for the synthesis of fluorinated pyrido[1,2-a]benzimidazoles have been developed, and a series of such compounds has been obtained and studied for biological activity. In particular, 5,6-difluoro-2-cyanobenzimidazole (II) was synthesized for the first time using the reaction of 1,2-diamino-4,5-difluorobenzole (I) with cyanoacetic ether. Pyrido[1,2-a… (More)
DOI: 10.1007/s11094-006-0023-9


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