Synthesis and antiviral activity of propargyl-hydroxymethyl derivatives of uracil and adenine

Acetylene nucleotide derivatives, containing a fragment with a carbon-carbon triple bond at different positions of the heterocyclic base, ribosyl ring, or acyclic portion of the molecule are of interest as antiviral and antitumor agents [1, 2], and as intermediates for obtaining other biologically active substances [3-9]. We have previously established that… CONTINUE READING