Synthesis and antitussive activity of aminotetra- (and -hexa-) hydrodibenzofurans.


The synthesis of a novel series of antitussive agents is described. Two series of amino-substituted tetra- and hexahydrodibenzofurans were prepared and examined for antitussive activity in the guinea pig after cough elicited by electrical stimulation of the vagus nerve. A significant level of activity, comparable with that of codeine, was found in the… (More)


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@article{Matharu1977SynthesisAA, title={Synthesis and antitussive activity of aminotetra- (and -hexa-) hydrodibenzofurans.}, author={S. S. Matharu and Daniel A Rowlands and Jerry Taylor and Russell Westwood}, journal={Journal of medicinal chemistry}, year={1977}, volume={20 2}, pages={197-204} }