Synthesis and antitumoral activity of novel 3-(2-substituted-1,3,4-oxadiazol-5-yl) and 3-(5-substituted-1,2,4-triazol-3-yl) beta-carboline derivatives.

@article{Formagio2008SynthesisAA,
  title={Synthesis and antitumoral activity of novel 3-(2-substituted-1,3,4-oxadiazol-5-yl) and 3-(5-substituted-1,2,4-triazol-3-yl) beta-carboline derivatives.},
  author={Anelise S Nazari Formagio and Lilian Tatiani D{\"u}sman Tonin and Mary Ann Foglio and Christiana Madjarof and Jo{\~a}o de Carvalho and Willian Ferreira da Costa and Fl{\'a}via Pereira Fernandes Cardoso and Maria Helena Sarragiotto},
  journal={Bioorganic & medicinal chemistry},
  year={2008},
  volume={16 22},
  pages={9660-7}
}
Several novel 1-substituted-phenyl beta-carbolines bearing the 2-substituted-1,3,4-oxadiazol-5-yl and 5-substituted-1,2,4-triazol-3-yl groups at C-3 were synthesized and evaluated for their in vitro anticancer activity. The assay results pointed thirteen compounds with growth inhibition effect (GI(50)<100 microM) for all eight different types of human cancer cell lines tested. The beta-carbolines 7a and 7h, bearing the 3-(2-metylthio-1,3,4-oxadiazol-5-yl) group, displayed high selectivity and… CONTINUE READING
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