Synthesis and antitumor evaluation of novel diarylsulfonylurea derivatives: molecular modeling applications.

@article{ElSherbeny2010SynthesisAA,
  title={Synthesis and antitumor evaluation of novel diarylsulfonylurea derivatives: molecular modeling applications.},
  author={Magda A. El-Sherbeny and Alaa A-M Abdel-Aziz and M. Al Jabr Ahmed},
  journal={European journal of medicinal chemistry},
  year={2010},
  volume={45 2},
  pages={689-97}
}
Some new ethyl 2-[3-(4-unsubstituted or 4-substituted phenylsufonyl)ureido]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylates 3a-c, 2-[3-(phenylsulfonyl)ureido]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carbohydrazides 4a-f, 3-phenylsulfonyl-6,7,8,9-tetrahydro-5H-cyclohepta[1',2':4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)dione 5 and 3-(phenylsulfonyl)-1-[3-(alkylaminocarbonyl or substituted piperazinylcarbonyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl]ureas 6a-d have been… CONTINUE READING