Synthesis and antitumor activity of spergualin analogues. I. Chemical modification of 7-guanidino-3-hydroxyacyl moiety.

@article{Umeda1985SynthesisAA,
  title={Synthesis and antitumor activity of spergualin analogues. I. Chemical modification of 7-guanidino-3-hydroxyacyl moiety.},
  author={Yasuko Umeda and Minoru Moriguchi and Hirohisa Kuroda and Terukazu Nakamura and Hironobu Iinuma and Tomio Takeuchi and Hamao Umezawa},
  journal={The Journal of antibiotics},
  year={1985},
  volume={38 7},
  pages={886-98}
}
Many analogues and derivatives of an antitumor antibiotic, spergualin, were synthesized, and the relationships between the structure and the activity against mouse L-1210 tumor were studied. Both modification of the 15-hydroxyl group and alteration of chain-length of the omega-guanidinoacyl moiety affected the activity. 15-Deoxyspergualin (18, 1-amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-d ion e) and its analogue 25 (1-amino-21-guanidino-11-hydroxy-4,9,12-triazauneicosane-10,13… CONTINUE READING

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