Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives.

@article{Xu2015SynthesisAA,
  title={Synthesis and antitumor activity of novel 2-substituted indoline imidazolium salt derivatives.},
  author={Xiao-Liang Xu and Chun-Lei Yu and Wen Chen and Ying-Chao Li and Li-Juan Yang and Yan Li and Hong-Bin Zhang and Xiaodong Yang},
  journal={Organic \& biomolecular chemistry},
  year={2015},
  volume={13 5},
  pages={
          1550-7
        }
}
A series of novel 2-substituted indoline imidazolium salt derivatives has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of a substituted benzimidazole ring and substitution of the imidazolyl-3-position with a naphthylacyl or 2-naphthylmethyl group were vital for modulating the cytotoxic activity. Compound 25 was found to be the most potent derivative with IC50 values of 0.24-1.18 μM, and exhibited cytotoxic activity… 
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