Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines.


Synthesis of fluorocyclopentenyl pyrimidine nucleosides 6-9 was enantiopurely accomplished employing oxidative rearrangement, RCM reaction and electrophilic fluorination starting from d-ribose. Cytosine analog 8 was found to exhibit significant anticancer activity in various human tumor cell lines.

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@article{Jeong2007SynthesisAA, title={Synthesis and antitumor activity of fluorocyclopentenyl-pyrimidines.}, author={Lak Shin Jeong and Long Zhao and Won Jun Choi and Shantanu Pal and Yeon Hee Park and Sang Kook Lee and Moon Woo Chun and Young Boo Lee and Chang Ho Ahn and Hyung Ryong Moon}, journal={Nucleosides, nucleotides & nucleic acids}, year={2007}, volume={26 6-7}, pages={713-6} }