Synthesis and antitumor activity of conjugates of 5-fluorouracil and chito-oligosaccharides involving a hexamethylene spacer group and carbamoyl bonds.

Abstract

With the object of providing an oligomeric prodrug of 5-fluorouracil (5FU) with reduced side-effects, affinity for tumor cells and high antitumor activity, 5FU was covalently attached to three chito-oligosaccharides (COS) through hexamethylene spacer groups via carbamoyl bonds. The ability of these conjugates to prolong the life of lymphocytic leukemia mice… (More)

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Cite this paper

@article{Ouchi1990SynthesisAA, title={Synthesis and antitumor activity of conjugates of 5-fluorouracil and chito-oligosaccharides involving a hexamethylene spacer group and carbamoyl bonds.}, author={Takehiko Ouchi and Tadao Banba and Tadashi Matsumoto and S. Suzuki and M Suzuki}, journal={Drug design and delivery}, year={1990}, volume={6 4}, pages={281-7} }