Synthesis and antitumor activity of 20-O-linked nitrogen-based camptothecin ester derivatives.

Abstract

A series of nitrogen-based 20S-hydroxyl camptothecin ester derivatives were prepared. 3-Aminopropionate of camptothecin was found more cytotoxic in vitro on several human tumor cell lines than 3-amidopropionate of camptothecin. Ester 16 showed best antitumor activity in vivo and in vitro in all esters we prepared.

Cite this paper

@article{Wang2004SynthesisAA, title={Synthesis and antitumor activity of 20-O-linked nitrogen-based camptothecin ester derivatives.}, author={Cun-ying Wang and Xian-dao Pan and Hongyan Liu and Zhao-di Fu and Xian-yong Wei and Lixi Yang}, journal={Bioorganic & medicinal chemistry}, year={2004}, volume={12 13}, pages={3657-62} }