Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives.


Twenty-six naturally occurring oleanolic acid saponins and their derivatives, 16 of which were synthesized in this study, were preliminarily evaluated against human cancer cells. From SAR studies, the presence of α-l-rhamnosyl residue at the terminal of both C-3 and C-28 position for oleanolic acid bidesmosides was important to enhance cytotoxicity, and… (More)
DOI: 10.1016/j.ejmech.2013.04.016


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