Synthesis and antitumor activities of [1,2,4] triazolo [1,5-a] pyrimidines

@inproceedings{Ping2007SynthesisAA,
  title={Synthesis and antitumor activities of [1,2,4] triazolo [1,5-a] pyrimidines},
  author={Gong Ping},
  year={2007}
}
Aim To discovery novel compounds of antitumor activities,a series of [1,2,4]triazolo[1,5-a]pyrimidine derivatives were designed and synthesized.Methods Starting with γ-butyrolactone,followed by cyclization,chlorination,substitution,etherification,and aminomethylation,7-anilino-5-methyl-2-(3-((5-(substituted-aminomethyl)furan-2-yl)methylthio)propyl)[1,2,4]triazolo[1,5-a]pyramidine type of compounds were synthesized and their antitumor activities were evaluated with Bel-7402 and HT-1080 in vitro… CONTINUE READING

Similar Papers