Synthesis and antiproliferative activity of ligerin and new fumagillin analogs against osteosarcoma.

@article{Blanchet2014SynthesisAA,
  title={Synthesis and antiproliferative activity of ligerin and new fumagillin analogs against osteosarcoma.},
  author={Elodie Blanchet and Marieke Vansteelandt and Ronan Le Bot and Maxim Egorov and Yann Guitton and Yves François Pouchus and Olivier Grovel},
  journal={European journal of medicinal chemistry},
  year={2014},
  volume={79},
  pages={244-50}
}
Ligerin (1) is a natural chlorinated merosesquiterpenoid related to fumagillin (2) exhibiting a selective antiproliferative activity against osteosarcoma cell lines and an in vivo antitumor activity in a murine model. Semisynthesis of ligerin analogs was performed in order to study the effects of the C3-spiroepoxide substitution by a halogenated moiety… CONTINUE READING