Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase.

@article{Zhu2011SynthesisAA,
  title={Synthesis and antiproliferative activities against Hep-G2 of salicylanide derivatives: potent inhibitors of the epidermal growth factor receptor (EGFR) tyrosine kinase.},
  author={Zhen-Wei Zhu and Lei Shi and Xiao-Ming Ruan and Ying Yang and H. Li and Suo-Ping Xu and H. L. Zhu},
  journal={Journal of enzyme inhibition and medicinal chemistry},
  year={2011},
  volume={26 1},
  pages={
          37-45
        }
}
A series of salicylanilide derivatives (compounds 1-32) were synthesised by reacting substituted salicylic acids and anilines. The chemical structures of these compounds were determined by (1)H-NMR, electrospray ionisation mass spectrometry (ESI-MS) and elemental analysis. The compounds were assayed for their antiproliferative activities against the Hep-G2 cell line by the 3-(4,5-dimethylthylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Among the compounds tested, 22 and 28 showed… CONTINUE READING