Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates.

  title={Synthesis and antioxidant activity of long chain alkyl hydroxycinnamates.},
  author={Jos{\'e} C J M D S Menezes and Shrivallabh P Kamat and Jos{\'e} A S Cavaleiro and Alexandra Gaspar and Jorge Garrido and Fernanda Borges},
  journal={European journal of medicinal chemistry},
  volume={46 2},
Long chain alkyl hydroxycinnamates (8-21) were synthesized from the corresponding half esters of malonic acid (5-7) and benzaldehyde derivatives by Knoevenagel condensation. The total antioxidant capacity of these hydroxycinnamyl esters was evaluated using DPPH and ABTS assays. The observed antioxidant activity was highest for esters of caffeic acid followed by sinapic esters and ferulic esters. The parameters for drug-likeness of these hydroxycinnamyl esters were also evaluated according to… CONTINUE READING