Synthesis and antimycobacterial activity of some phthalimide derivatives.

  title={Synthesis and antimycobacterial activity of some phthalimide derivatives.},
  author={H Seval Akg{\"u}n and Irem Karamelekoğlu and Barkın Berk and Işıl Aksan Kurnaz and Gizem Sarıbıyık and Sinem Oktem and Tanıl Kocag{\"o}z},
  journal={Bioorganic & medicinal chemistry},
  volume={20 13},
Structurally modified phthalimide derivatives were prepared through condensation of phthalic and tetrafluorophthalic anhydride with selected sulfonamides with variable yields. All compounds were screened for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra (ATCC 25177) using a micro broth dilution technique. The fluorinated derivatives (compounds 2c, 2d, 2f and 2h) had antimycobacterium activity comparable with classical sulfonamide drugs. The minimum inhibitory… CONTINUE READING