Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.

@article{Abad2012SynthesisAA,
  title={Synthesis and antimitotic and tubulin interaction profiles of novel pinacol derivatives of podophyllotoxins.},
  author={A. Abad and J. L{\'o}pez-P{\'e}rez and E. del Olmo and L. Garc{\'i}a-Fern{\'a}ndez and A. Francesch and C. Trigili and I. Barasoain and J. Andreu and J. F. D{\'i}az and A. San Feliciano},
  journal={Journal of medicinal chemistry},
  year={2012},
  volume={55 15},
  pages={
          6724-37
        }
}
Several pinacol derivatives of podophyllotoxins bearing different side chains and functions at C-7 were synthesized through reductive cross-coupling of podophyllotoxone and several aldehydes and ketones. While possessing a hydroxylated chain at C-7, the compounds retained their respective hydroxyl group with either the 7α (podo) or 7β (epipodo) configuration. Along with pinacols, some C-7 alkylidene and C-7 alkyl derivatives were also prepared. Cytotoxicities against neoplastic cells followed… Expand
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