Synthesis and antimicrobial activity of novel structural hybrids of benzofuroxan and benzothiazole derivatives.

@article{Chugunova2015SynthesisAA,
  title={Synthesis and antimicrobial activity of novel structural hybrids of benzofuroxan and benzothiazole derivatives.},
  author={Elena Chugunova and Carla Boga and Ivan Sergeevich Sazykin and Silvia Cino and Gabriele Micheletti and Andrea Mazzanti and Marina Alexandrovna Sazykina and Alexander R. Burilov and Ludmila Eugenevna Khmelevtsova and Natalia V Kostina},
  journal={European journal of medicinal chemistry},
  year={2015},
  volume={93},
  pages={
          349-59
        }
}

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References

SHOWING 1-10 OF 57 REFERENCES
Synthesis and antibacterial activity of some substituted 2-phenyl benzothiazole
Discovery and development of effective as well as safe drugs has brought a progressive era in human healthcare that is accompanied by drug resistant bacterial strains. So, there is constant need of
Pharmacological properties of furoxans and benzofuroxans: recent developments.
TLDR
New anti-ulcer drugs, calcium channel modulators and vasodilator derivatives were described and they are currently in study.
Synthesis, Genotoxicity and UV-protective Activity of New Benzofuroxans Substituted by Aromatic Amines
The synthesis of new organic compounds possessing properties, which can be used for biological or pharmaceutical purpose, is very challenging and is a current trend in heterocyclic chemistry. So
2-Amino-Substituted Benzothiazoles: Different Methods of the Synthesis
TLDR
The present review focuses on different methods of the substituted benzothiazoles with potential activities that are n ow in development.
BENZOTHIAZOLE THE MOLECULE OF DIVERSE BIOLOGICAL ACTIVITIES
TLDR
This work aims to contribute towards the development of benzotriazole-based drugs with high bioactivity and low toxicity in the field of medicinal chemistry.
SIGNIFICANCE OF BENZOTHIAZOLE MOIETY IN THE FIELD OF CANCER
TLDR
The various synthetic molecules developed to promote the benzothiazole moiety in the modern era of anticancer agent are emphasized.
NO Donor and Biological Properties of Different Benzofuroxans1
TLDR
The simple benzofuroxans considered here are devoid of the capability to release NO, they weakly stimulate sGC as well as manifest feeble vasodilating properties by a mechanism that does not involve a thiol-induced NO production.
...
...