Synthesis and antimicrobial activity of new polyfunctionally substituted pyridines and their fused derivatives

Abstract

Ethyl pyruvate (EP) on reacting with malononitrile or isothiocyanates gives the pyridine derivati ves 5 and 9a , b , respecti vely. Chalcone deri vati ve of EP reacts with malononitrile to yield the pyran derivative which in turn IS transformed into pyridine derivative 14. Reactivity of 5 and 9a towards di fferent organic reagents has been investigated… (More)

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